Pulmonary responses of the guinea pig to inhaled A23187: a
brief review.
Silbaugh SA, Sofia MJ, Hamill RL, Stengel PW.
Eli Lilly and Company, Indianapolis, Indiana 46285.
The pulmonary effects of inhaled A23187 are reviewed. Guinea pigs challenged
with this divalent cationic ionophore rapidly develop airway obstruction, which
is maintained for at least 4 h. Pulmonary inflammation and increased airway
responsiveness are also observed. Pharmacologic manipulations suggest that these
actions are due to the release of multiple mediators. We have found A23187
challenge to be valuable as an approach for testing potential asthma drugs.
Publication Types:
PMID: 1295367
